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ACCESS INQUIRY LIST JAPANESE A A About us Courses ResearchCenters Internationalexchange For currentstudents Cooperation About us Courses Research Centers International exchange For current students Access Cooperation HomeAbout usList of LaboratoryBioorganic Chemistry of Natural Products Chemistry and Life Science Bioorganic Chemistry of Natural Products IntroductionOur research targets are highly bioactive natural products, especially marine natural toxins. The major works are screening, isolation, structural determination and elucidation of biosynthesis, target proteins, and biological functions. Tetrodotoxin: Analytical methods (LC/MS), novel natural analogues, origin, biosynthesis, toxin binding protein and electrophysiology.Diarrheic shellfish toxins: Roles of okadaic acid binding protein in sponge and significance of structural conversion and accumulation in bivalves.Paralytic shellfish toxins: Mechanism for non-toxic mutation of toxin producing dinoflagellate, and synthesis of biosynthetic intermediates and their identification.Other marine toxins: Biosynthesis of kainoids (domoic acid and kainic acid) and mode of action of polycavernosides and maitotoxin.Bioactive compounds from marine organisms and microorganisms.Electrophysiological recordings of voltage-gated sodium channels for elucidating mode of action of marine natural products. URL https://www.agri.tohoku.ac.jp/bukka/English%20Version.htm Keywords Marine toxins, Natural products, Structural elucidation, Biosynthesis, Pharmacology Staff Professor YAMASHITA MARIAssociate professor KONOKI KEIICHI Assistant professor CHO YUKOAssistant professor KUDO YUTA (学際研兼任) 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan TEL. +81-22-757-4003 FAX. +81-22-757-4020 ©Tohoku University Graduate School of Agricultural Science / Faculty of Agriculture