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Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Themes Researchers JP Top Medical Advanced Molecular Transformations by Organocatalysts Advanced Molecular Transformations by Organocatalysts JAPANESEINQUIRY update：2020/06/16     NEXT PREV Features and Uniqueness The development of organic molecules which function as a catalyst has been extensively investigated to achieve selective and efficient transformation of organic molecules. Brønsted acids and bases are commonly employed as the catalyst in synthetic organic chemistry. To aim at their functionalization, axially chiral phosphoric acids and axially chiral guanidine bases have been developed as chiral Brønsted acid and base catalysts, respectively. A variety of optically active compounds has been synthesized through the development of highly stereoselective reactions using these catalysts. Practical Application The development of chiral Brønsted acid and base catalysts has been accomplished as recoverable and reusable organocatalysts and highly stereoselective molecular transformations have been established using these catalysts. The present methodology is applicable to process chemistry in preparing medicines and relevant compounds on the basis of the selective and efficient molecular transformations thus developed with reduction of the waste material. Keywords Asymmetric Synthesis Optically Active Compounds Organocatalysts Catalysts Synthetic Medicines Researchers Graduate School of Science Masahiro Terada, ProfessorPhD Laboratory Website researchmap Laboratory Website researchmap Related Information 1) Patents:Title of Invention: Process for production of optically active amines by stereoselective nucleophilic addition reaction of imines with C nucleophiles using chiral phosphoric acid derivative.Priority Application: JP 2004-17725, Application Date: 2004-01-26Application Number: WO 2005-JP962, Applicant Date: 2005-01-26Patent Number: WO 2005070875 A1, Publication Date: 2005-08-04Application Number: US 2006-587279, Application Date: 2006-10-12Patent Number: US 20070142639 A1, Publication Date: 2007-06-212) Literatures:Visit web site of the Laboratory Browsing History Common Keywords Development of New Reactions Using Organocatalyst [ 林 雄二郎 教授 ] User Who Reviewed This Content Also Reviewed Extracorporeal Shock Wave Therapy as a New, Non-Invasive Angiogenic Therapy [ SHIMOKAWA Hiroaki Professor ] Advanced Educational Environment with Interactive Instruction System IMPRESSION [ Takashi Mitsuishi Associate Professor ] A novel crystal growth via controlling an energy relationship between crystal and melt with applying an electric field [ Satoshi Uda Specially Appointed Professor(Research) ] Research Profiles ©TOHOKU UNIVERSITY How to Use FAQ For Researchers Site Policy [jp] ©TOHOKU UNIVERSITY Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Fields Themes Researchers 日本語 ENGLISH Close