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--> Frontier Research Institute for Interdisciplinary SciencesTohoku University Directions 日本語 English CONTACT 日本語 English About FRISGreetingsOverviewMissionsOrganizationTenure track system in FRISMaps & DirectionsPublicationAnnual MeetingAbstract for Annual MeetingConsultation DeskResearcherAdvanced Interdisciplinary Research DivisionHiroshi MasumotoTakehito ShimatsuTakashi ItohKenji TomaShinsuke NiwaTakaaki TomaiCreative Interdisciplinary Research DivisionYuanyuan GuoMasaki OkumuraNguyen Tuan HungHiroshi UenoToshiharu IchinoseYuta KudoHiroya AbeYuta NakayasuNaoya KitajimaDaniel Pastor-GalanYasunori OkamotoTakuro IshiiMasaki YamadaYuta YamaneKexin XiongKohei ShimokawaShinichi SatoKotaro YasuiSUN SaiYuji SaitoAtsushi TaharaKyoko ChibaYuka HatanoHakuto SuzukiKaoru HiramotoHideaki T. MatsubayashiAseel Mahmoud Suleiman MarahlehSakura KiuchiShigeo S. KimuraBin Ho LeTom WellingHiroyuki UechiFumi MurakoshiChao TangTakahiro ChibaIzumi MatsudairaYuka FujikiLinda ZhangYueh Hsuan WengManaging & Planning DivisionJunji SaidaHideaki FujiwaraEndowed Research DivisionsSenior-advisorTomoyuki YamayaVisiting Professors / Collaborative ResearchersSpecially-appointedOne-time membersSeiji KojimaDaisuke SuzukiHidenobu YajimaHirokazu KawamuraShozo FurumotoKanako ShojikiYiwen ZhangYuiko Morita-FujimuraPierre Antoine GESLINYuma TakahashiTatsuya SatoYuki FuruseKim Sung HoonYui ArimatsuYuichiro FujiokaRui NouchiAyako NakamuraNozomi SaitoTetsuya KajitaHiroyasu HatakeyamaYuki ShibazakiSohei TasakiHitomi AnzaiYuji ShimogonyaHideaki YamamotoHiroki TakikawaTakeshi InoueTakashi MisakaMikito TanakaGao JunhongNaoya OnizawaYasufumi ArakiDaisuke SaitoShusaku SugimotoMasafumi NakayamaHirofumi NodaMasanori IzumiMichiko KanoKohji TsumuraKenichi FunamotoMasahiro KayamaAtsushi NarukoShinsuke SuzukiGen HayaseDaisuke YoshinoTakashi ShimonishiHisashi InoueTakayuki KojimaNobuyuki MatsumotoSeiji KamadaSae KanekoTomoki KimuraYuichiro NakajimaShimpei EndoRui YamadaHisashi KinoYuki Suzuki Fumihiro KanedaYuji NashimotoYusuke SatoShuhei ObaraYasukazu DaigakuHanae AokiHiroki IdaAlimu TuohetiKaoru KakinumaJoji KusuyamaJiuhui HanYang CaoJun ZhangKohei TamuraChaoliang ZhangTomokatsu OnagaMasanori WakizakaKohei IchikawaTomomi TsunematsuChrystelle BERNARDKozue ShiomiYohei KawazuraSatoshi IihamaTakuya MabuchiFeatureTopicsFRIS InterviewsFRIS Interviews #01FRIS Interviews #02FRIS Interviews #03FRIS Interviews #04FRIS Interviews #05FRIS Interviews #06FRIS Interviews #07FRIS Interviews #08FRIS Interviews #09FRIS Interviews #10FRIS Interviews #11FRIS Interviews #12FRIS Interviews #13FRIS Interviews #14FRIS Interviews #15FRIS Interviews #16FRIS Hub MeetingFRIS Hub Meeting 2024FRIS Hub Meeting 2023FRIS Hub Meeting2022FRIS Hub Meeting2021FRIS Hub Meeting archiveProgramsOpen Research ProposalResearch ProjectsRecruitOpen Staff PositionsFRIS Regulations pertaining to the tenure track systemHandbook for International ResearchersFRIS FundFRIS Fund for Early-Career Independent ResearchersLINK Researcher HOME en Researcher Creative Interdisciplinary Research Division Shinichi Sato ResearcherAdvanced Interdisciplinary Research DivisionCreative Interdisciplinary Research DivisionManaging & Planning DivisionEndowed Research DivisionsSenior-advisorVisiting Professors / Collaborative ResearchersSpecially-appointedOne-time members Shinichi Sato Associate professorLife and Environments Mentor Information Professor Minoru Ishikawa (Graduate School of Life Sciences) researchmap Website 東北大学研究者紹介--> Research Fields Synthetic Organic Chemistry, Chemical Biology Research Subjects Tyrosine-Specific Bioconjugation Antibody Chemical Modification Catalyst-Proximity Protein Chemical Labeling Academic Society Membership The Chemical Society of Japan, The Pharmaceutical Society of Japan, The Japanese Peptide Society, International Chemical Biology Society Research Outline   Bioconjugation methods are techniques that have been extensively studied for covalent bond formation between a specific amino acid residue of a protein and a synthetic small compound. The methods are highly important in making protein-based biomaterials for therapeutic and biotechnology industries. In order to achieve reliable protein bioconjugation, the following requirements should be met: (1) stable covalent bond formation, (2) rapid reaction in aqueous solution, and (3) high conversion under physiological pH and mild temperature. We have developed tyrosine-specific bioconjugation methods with ruthenium photocatalysts, hemin, enzymes and electrochemistry. The relative hydrophobicity of tyrosine combined with the π−π stacking tendency of the aromatic rings results in generally low accessibility. We have developed site-selective protein modification by targeting surface-exposed tyrosine residues and applied to antibody site-selective functionalization. Furthermore, based on my unique methodology which controls the protein bioconjugation using single-electron transfer in proximity to the catalyst on the nanometer scale, we have developed a method for target-selective protein labeling in a protein mixture. This method enables us to identify target proteins of bioactive molecules. Related Posts Topics2021.06.01Researchers have created a new nanometer-scale proximity labeling system that targets histidine res PAGE TOP Frontier Research Institute for Interdisciplinary Sciences About FRIS GreetingsOverviewMissionsOrganizationTenure track system in FRISMaps & DirectionsPublicationAnnual MeetingConsultation Desk Researcher Advanced Interdisciplinary Research DivisionCreative Interdisciplinary Research DivisionManaging & Planning DivisionEndowed Research DivisionsSenior-advisorVisiting Professors / Collaborative ResearchersSpecially-appointedOne-time members Feature TopicsFRIS InterviewsFRIS Hub Meeting Research Programs Open Research ProposalResearch Projects Recruit Open Staff PositionsHandbook for International Researchers FRIS CoRE FRIS CoRE FRIS Fund FRIS Fund for Early-Career Independent Researchers External Links for Early Career Researcher Support Division for Interdisciplinary Advanced Research and Education (DIARE) Ensemble Project for Early Career Researchers Support Program for the Article Processing Charge webmail LINK Copyrights © Frontier Research Institute for Interdisciplinary Sciences, Tohoku University All rights reserved. no cache